![]() ![]() coli are surrounded by an outer envelope across which few proteins are transported. One of the challenges of enhancing the therapeutic capabilities of this beneficial microbe was to enable it to secrete proteins into its surroundings. ![]() The work is described in the newest issue of Cell Host & Microbe. When engineered to secrete an antibody that blocks inflammation, this " smart microbe", was as efficacious as a systemically delivered antibody, the mainstay of current therapy, in limiting the development of colitis in a mouse model of inflammatory bowel disease (IBD). coli), Nissle 1917, to secrete proteins of therapeutic value into its surroundings. Investigators at Massachusetts General Hospital (MGH), a founding member of Mass General Brigham (MGB), have engineered a strain of the probiotic Escherichia coli (E. One goal is to develop smart microbes that release therapeutic payloads at sites of disease, thus maintaining therapeutic efficacy while limiting many of the side effects that can be associated with the systemic administration of conventional drugs. ![]()
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